Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis.
نویسندگان
چکیده
PURPOSE Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. METHODS In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. RESULTS Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. CONCLUSION We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
منابع مشابه
Correlation between CRP and early failure of arteriovenous
Background: Arteriovenous Fistula (AVF)is the ideal method of vascular access for patients on maintenance hemodialysis (HD).Therefore it is an important part of treatment in HD.There are several observations that indicate the role of inflammation in failure of AVF.The aim of this study was to evaluate the hematologic and inflammatory biomarkers in early AVF failure. Methods : This case-cont...
متن کاملPrediction of arteriovenous fistula stenosis and failure via in vivo inflammation and fibrin molecular imaging
Dialysis Access is the “lifeline” for 1.5 million end-stage renal disease (ESRD) patients across the world. Effective hemodialysis treatment requires reliable large caliber vascular access. The preferred hemodialysis access is an arteriovenous fistula (AVF) because of its lower infection rate, lower hospitalization rate and relatively longer longevity compared to grafts.(1, 2) However, the prim...
متن کاملPrediction of arteriovenous fistula stenosis and failure via in vivo inflammation and fibrin molecular imaging
Dialysis Access is the “lifeline” for 1.5 million end-stage renal disease (ESRD) patients across the world. Effective hemodialysis treatment requires reliable large caliber vascular access. The preferred hemodialysis access is an arteriovenous fistula (AVF) because of its lower infection rate, lower hospitalization rate and relatively longer longevity compared to grafts.(1, 2) However, the prim...
متن کاملMeasurement of hemodynamic and anatomic parameters in a swine arteriovenous fistula model.
PURPOSE Although arteriovenous fistulae (AVFs) are currently the preferred mode of permanent hemodialysis access they do have significant problems due to initial non-maturation and a later venous stenosis. These problems appear to have been exacerbated following a push to increase AVF prevalence in the US. The reasons for both AVF non-maturation and the later venous stenoses are unclear but are...
متن کاملData Mining Performance in Identifying the Risk Factors of Early Arteriovenous Fistula Failure in Hemodialysis Patients
Background and Objectives: Arteriovenous fistula is a popular vascular access method for surgical treatment of hemodialysis patients. The method, however, is associated with a high rate of early failure varying in the range of 20-60%. Predicting early Arteriovenous fistula failure and its risk factors can help reduce its incidence, its hospitalization rate, and associated costs. In this study, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The journal of vascular access
دوره 15 1 شماره
صفحات -
تاریخ انتشار 2014